Convergent synthetic methodology for the construction of self-adjuvanting lipopeptide vaccines using a novel carbohydrate scaffold

Convergent synthetic methodology for the construction of self-adjuvanting lipopeptide vaccines using a novel carbohydrate scaffold

Blog Article

A novel convergent synthetic strategy for the construction simply southern cat shirt of multicomponent self-adjuvanting lipopeptide vaccines was developed.A tetraalkyne-functionalized glucose derivative and lipidated Fmoc-lysine were prepared by novel efficient and convenient syntheses.The carbohydrate building block was coupled to the self-adjuvanting lipidic moiety (three lipidated Fmoc-lysines) on solid support.Four copies of a group A streptococcal B cell epitope (J8) were then conjugated to the glyco-lipopeptide using a copper-catalyzed cycloaddition reaction.

The approach was elaborated by the preparation of a second vaccine candidate which incorporated an iphone 14 price chicago additional promiscuous T-helper epitope.